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High Purity Children Li Zhu 2000iu / 5000iu HCG Injections For Weight Loss

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Marvel Pharma Inc.

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Telephone : 86-0745-2722878

22nd Floor, New Times Plaza, Hecheng, Huaihua 418000, Hunan CHINA

Product Details:

Place of Origin: China
Brand Name: Lizhu
Certification: GMP
Model Number: HCG ( human chorionic gonadotropin )

Payment & Shipping Terms:

Minimum Order Quantity: 1 kit
Price: Negotiable
Packaging Details: Discreet packing
Delivery Time: 24 hrs
Payment Terms: Western Union, MoneyGram
Supply Ability: 100000kits/month
Detailed Product Description
Product Name: Li Zhu Hcg 5000iu Injection Vial Specification: 5000iu/vial, 10vials/kit, 50000iu/kit
Usage: Used For Weight Loss HCG Injection Price: Negotiable
HCG Injection Dosage: Around 200 Iu Per Day HCG Injection Half Life: 28 Hours
HCG Injection Top Color: Red Tops Hcg HCG Injection Side Effects: Severe Pelvic Pain; Swelling Of The Hands Or Legs; Stomach Pain And Swelling; Shortness Of Breath; Weight Gain; Diarrhea; Nausea Or Vomiting; Or. Urinating Less Than Normal.

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HCG stands for Human Choriogonadotropin, the hormone produced by pregnant women in the early stages of pregnancy. Research suggests a small, daily HCG Injection (approx. 125 IU to 200 IU) may result in a weight loss of 1 to 2 lbs per day, and often more. This program must be accompanied by the VLCD (very low calorie diet, of apprx. 500 calories/day).

Our approach to the HCG Diet is very simple and cost efficient. Our Customers can order real injectable HCG through our shop, without a prescription. Doctors and weight loss clinics are cashing in ridiculously on this popular diet by imposing high consultation, prescription, and administration fees. Reportedly, the charge for a month of HCG Injections is around US$ 1000. Save this money right now and get the same quality product at a fraction of this cost !


Action of HCG

The HCG Hormone (human chorionic gonadotropin) is usually produced by a woman during pregnancy. Besides other functions it supports the developing fetus, by making sure there are enough resources for a healthy growth. The nutrition is generally extracted from the food intake of the pregnant women.

If a shortage of food intake is detected, HCG will utilize the mother’s fat reserves to feed the growing baby. This simple, and yet very effective emergency measure, developed by nature, is used by HCG Dieters. After HCG is administered, the body is tricked into an emergency situation by starting the VLCD (very low calorie diet). The body will start breaking up the fat reserves, and dispose of these gradually.

You do not have to be pregnant to take advantage of this process. HCG can be used by women and men. It is perfectly safe, just think that a fetus is subjected to this hormone 9 month long, in much higher concentrations than what is actually needed for the HCG Diet.

The internet is full of success stories and postings by dieters that achieved stunning long term results with this system. The HCG Diet is truly the most effective system to shed weight.

Dr. Simeons Protocol

It all started when the late British Physician, Dr. A. T. W. Simeons discovered the HCG weight loss protocol over fifty years ago. He devoted years to researching various patients suffering from obesity. 

During this time, Simeons noticed several important factors including the lack of symptoms one would expect from a patient on a very low calorie diet. For example, his patients had no headaches, hunger pains, weakness, or irritability as long as the low calorie diet was combined with HCG Shots

Tens of thousands of people used this simple, inexpensive, safe treatment and achieved substantial and permanent weight loss. 

The main problems that overweight people deal with are massive, intense, constant physical hunger; food cravings and uncontrollable urges to eat when not hungry; low metabolism; and an high amount of fat stored in stubborn secure problem areas such as the hips, thighs, buttocks, and waist. The HCG weight loss plan helps with all these problem along with the HCG Injections.

High Purity Children Li Zhu 2000iu / 5000iu HCG Injections For Weight Loss


Nolvadex, Clomid and HCG in Post Cycle Therapy (PCT)

One of the most frequently asked questions on MuscleTalk is how to properly use the Post Cycle Therapy (PCT) drugs Nolvadex, Clomid and HCG correctly.

(A note to Americans - when I say 'oestrogen' I mean 'estrogen' - we spell it correctly in the UK!)


Why Bodybuilders Use Clomid
Clomid is a generic name for Clomiphene Citrate and is a synthetic oestrogen. It is prescribed medically to aid ovulation in low fertility females. Another generic name is Serophene.

Most anabolic steroids, especially the androgens, cause inhibition of the body's own testosterone production. When a bodybuilder comes off a steroid cycle, natural testosterone production is zero and the levels of the steroids taken in the blood are diminishing. This leaves the ratios of catabolic : anabolic hormones in the blood high, hence the body is in a state of catabolism, and, as a result, much of the muscle tissue that was gained on the cycle is now going to be lost.

Clomid stimulates the hypothalamus to, in turn stimulant the anterior pituitary gland (aka hypophysis) to release gonadotrophic hormones. The gonadotrophic hormones are follicle stimulating hormone (FSH) and luteinizing hormone (LH - aka interstitial cell stimulating hormone (ICSH)). FSH stimulates the testes to produce more testosterone, and LH stimulates them to secrete more testosterone. This feedback mechanism is known as the hypothalamic-pituitary-testes axis (HPTA), and results in an increase of the body's own testosterone production and blood levels rise, to, in part, compensate for the diminishing levels of exogenous steroids. This is vital to minimise post cycle muscle losses.

Not all steroids do cause shut down of the feedback mechanism. Everyone is different and you must also take into account how long you have been using a certain steroid and at what dose in order to determine if you need Clomid or not.

Clomid also works as an anti-oestrogen. As it's a weak synthetic oestrogen, it binds to oestrogen receptors on cells blocking them to oestrogen in the blood. This minimises the negative effects like gynecomastia and water retention that may be a result of oestrogen that has aromatised from testosterone.

It's effect as an anti-oestrogen are quite weak though, and it should not be relied upon if you are going to be using androgenic steroids that aromatise at a rapid rate, or if you are pre-disposed to gynecomastia. Arimidex and Nolvadex (Tamoxifen) are far more effective anti-oestrogens.


Important note: 

Clomid does not, as is often thought, stimulate the release of natural testosterone, but rather works at reducing the oestrogenic inhibition caused by the steroid cycle. It does this in a similar manner to the way it and Nolvadex block oestrogen receptors in nipples to combat gyno development, i.e. by blocking the oestrogen receptors in the hypothalamus and pituitary thus reducing the inhibition from the elevated oestrogen. This allows LH levels to return to normal, or even above normal levels, and in turn, natural testosterone levels to also normalise.

Inhibition of the HPTA is caused by either elevated androgen, oestrogen or progesterone levels. On cessation of the steroid cycle, androgen levels begin to fall and Clomid dosing is normally commenced according to the half-life of the longest acting drug in the system (see below).

This may also explain the reason individuals often find post-deca recovery more difficult, as the progesterone presence is untouched by the Clomid. We know that Clomid and Nolvadex (being very similar chemically) are both ineffective with regard to reducing progesterone related gyno, so it is reasonable to assume that Clomid has little effect against progesterone levels.


Clomid During A Cycle
When we use anabolic steroids, the level of androgens in the body rises causing the androgen receptors to become more highly activated, and through the HPTA, a signal tells our testes to stop producing testosterone. During a cycle the body has far higher than normal levels of androgens and, as long as this level is high enough, Clomid will not help to keep natural testosterone production up. It will be almost all but completely shut off, in theory.

Some heavy androgen users, however, do advocate a small burst of Clomid mid-cycle, though it must be hard for them to say if it really of any benefit, due to the amount of gear they are using. Therefore, the only purpose of Clomid during a cycle is as an anti-estrogen.


When To Take Clomid
The correct time to commence Clomid depends on the type and cycle of steroids you have been using. Different steroids have different half-lifes (indicates the time a substance diminishes in blood), and Clomid administration should be taken accordingly.

As we have seen above, Clomid taken when androgen levels in our blood are still high will be a waste. It is crucial to wait for androgen levels to fall before implementing our Clomid therapy. However, if taken too late we could possibly lose gains.


The list below determines when you should start Clomid. Select from the list any steroids you've used in your cycle and whichever one has the latest starting point is the time to commence Clomid. For example, if Dianabol, Sustanon and Winstrol were cycled, the time for administering Clomid should be 3 weeks post cycle, as Sustanon remains active in the body for the longest period of time.


Steroid Time after
last administration
  Length of
Clomid Cycle
Anadrol50/Anapolan50: 8 - 12 hours   3 weeks
Deca durabolan: 3 weeks   4 weeks
Dianabol: 4 - 8 hours   3 weeks
Equipoise: 17 - 21 days   3 weeks
Finajet/Trenbolone: 3 days   3 weeks
Primabolan depot: 10 - 14 days   2 weeks
Sustanon: 3 weeks   3 weeks
Testosterone Cypionate: 2 weeks   3 weeks
Testosterone Enanthate/Testaviron: 2 weeks   3 weeks
Testosterone Propionate: 3 days   3 weeks
Testosterone Suspension: 4 - 8 hours   2-3 weeks
Winstrol 8 - 12 hours   2-3 weeks


How To Take Clomid
Clomid has a long half-life (possibly 5 days), so there is no need to split up doses throughout the day. If Sustanon has been used and Clomid is commenced 3 weeks after the last injection, I would estimate that androgen levels are low enough to start sending the correct signals. If androgen levels are still a little high, we need to start at a high enough amount that will work or help, even if androgen levels are still a little high. Try 300mg on day 1; then use 100mg for the next 10 days; followed by 50mg for 10 days.


How to take Nolvadex for PCT
As an alternative to Clomid, which has been reported to have led to unwanted side effects such as visual disturbances in some users, Nolvadex can be employed. Nolvadex is a trade name for the drug Tamoxifen. Like Clomid, the half life of Nolvadex is relatively long enabling the user to implement a single daily dosing schedule. Administration would start as per the timescales outlined above and the duration would be identical to that of Clomid.

Typically, for a moderate-heavy cycle, the following dosages would be used: 
Day 1 - 100mg
Following 10 days - 60mg
Following 10 days - 40mg

Occasionally, heavier cycles containing perhaps Nandrolone (Deca) or Trenbolone which by definition are particularly suppressive of the HPTA, may require a slightly longer therapy. Likewise, more modest/shorter cycles may require lower dosages, perhaps dropping each by 20mg per day.

Some users like to use both Clomid and Nolvadex in their PCT in an attempt to cover all angles. An example of the dosages involved might be:

Day 1 - Clomid 200mg + Nolvadex 40mg 
Following 10 days - Clomid 50mg + Nolvadex 20mg 
Following 10 days - Clomid 50mg or Nolvadex 20mg

Of course, the examples provided are not set in stone and may be adjusted depending on the factors outlined above and individual variances.


Using HCG
It is our opinion that HCG is probably one of the most misunderstood and misused compounds in bodybuilding. Hopefully this information will go some way towards rectifying that for the members of MuscleTalk. HCG stands for Human Chorionic Gonadotrophin and is not a steroid, but a natural peptide hormone which develops in the placenta of pregnant women during pregnancy to controls the mother's hormones. (Incidentally, this is the reason you may hear of people testing for growth hormone (HGH) with a pregnancy testing kit - If their HGH shows 'pregnant', they've been ripped-off with cheaper HCG - but we digress slightly).

Its action in the male body is like that of LH, stimulating the Leydig cells in the testes to produce testosterone even in the absence of endogenous LH. HCG is therefore used during longer or heavier steroid cycles to maintain testicular size and condition, or to bring atrophied (shrunken) testicles back up to their original condition in preparation for post-cycle Clomid therapy. This process is necessary because atrophied testicles produce reduced levels of natural testosterone, this situation should be rectified prior to post-cycle Clomid therapy.

HCG administration post-cycle is common practice among bodybuilders in the belief that it will aid the natural testosterone recovery, but this theory is unfounded and also counterproductive. The rapid rise in both testosterone, and thus oestrogen due to aromatisation, from the administration of HCG causes further inhibition of the HPTA (Hypothalamic/Pituitary/Testicular Axis - feedback loop discussed above); this actually worsens the recovery situation. HCG does not restore the natural testosterone production.

The typically observed dosing of 2000 to 5000IU every 4 to 5 days causes such an increase in oestrogen levels via aromatisation of the natural testosterone that this has been responsible for many cases of gynecomastia.

From the above discussion it is clear that HCG is best used during a cycle, either to:

1) Avoid testicular atrophy, or
2) Rectify the problem of an existing testicular atrophy.


HCG Dosage
Smaller doses, more frequently during a cycle will give best overall results with least unwanted side effects. Somewhere between 500IU and 1000IU per day would be best over about a two-week period. These doses are sufficient to avoid/rectify testicular atrophy without increasing oestrogen levels too dramatically and risking gynecomastia. This dosing schedule also avoids the risk of permanently down-regulating the LH receptors in the testes.

It is important for the HCG administration to have been completed with 6 or 7 clear days before the onset of PCT in order to avoid inhibition of the Nolvadex and/or Clomid therapy. Also, a small daily dose (10-20mg) of Nolvadex would normally be used in conjunction with HCG in order to prevent oestrogenic symptoms caused by sudden increases in aromatisation.


Presentation and Administration of HCG
Synthetic HCG is often known as Pregnyl (generic name) and is available in 2500iu and 5000iu (not ideal for the above doses!). Administration of the compound is either by intra-muscular or subcutaneous injection. It comes as a powder which needs to be mixed with the sterile water. The powder is temperature-sensitive prior to mixing and should not be exposed to direct heat. After mixing, it should be kept refrigerated and used within a few weeks - though there are sterility issues which need to be considered after mixing.

Summary and Presentation of Clomid and HCG
Clomid and/or Nolvadex are more effective than HCG post cycle, but some long-term users like to use HCG during a cycle, or to prepare the testes for Clomid and/or Nolvadex therapy.

Clomid is available in 50mg tablets most commonly, but also comes in 25mg capsule, often in boxes of 24 tablets. Tamoxifen is made by a number of manufacturers and comes in 10mg or 20mg tablets, most commonly 30 x 20mg tablets. HCG generally comes in kits of three ampoules of powder needing to be mixed with the provided injectable water as 1500IU, 2500IU or 5000IU per ampoule kits.


                                     High Purity Children Li Zhu 2000iu / 5000iu HCG Injections For Weight Loss

What is HCG?

Human chorionic gonadotropin (HCG) is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation.

HCG is used to cause ovulation and to treat infertility in women, and to increase sperm count in men. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder.

HCG may also be used for other purposes not listed.


Important information

HCG is given as an injection under the skin or into a muscle. If you use HCG at home, your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject HCG if you do not fully understand how to give the injection and properly dispose of used needles and syringes.


Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache.

Slideshow: 14 Essential Health Screenings That All Men Should Consider

Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any symptoms of OHSS: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting, and urinating less than normal.

HCG can cause early puberty in young boys. Call your doctor if a boy using this medicine shows early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.

Using HCG can increase your chances of having a multiple pregnancy (twins, triplets, quadruplets, etc). A multiple pregnancy is a high-risk pregnancy for the mother and for the babies. Follow your doctor's instructions about any special care you may need during your pregnancy.

Although HCG can help you become pregnant, this medication is in the FDA pregnancy category X. This means that using the medication once you are pregnant can cause birth defects in the baby. Do not use HCG if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Before using HCG

You should not use this medication if you have ever had an allergic reaction to HCG, or if you have:
early puberty (also called precocious puberty); or
a hormone-related cancer (such as prostate cancer).
Before receiving HCG tell your doctor if you are allergic to any drugs or if you have:
a thyroid or adrenal gland disorder;
an ovarian cyst;
premature puberty;
cancer or a tumor of the breast, ovary, uterus, prostate, hypothalamus, or pituitary gland;
undiagnosed uterine bleeding;
heart disease;
kidney disease;
migraines; or
If you have any of these conditions, you may need a dose adjustment or special tests to safely use HCG.

Although HCG can help you become pregnant, this medication is in the FDA pregnancy category X. This means that using the medication once you are pregnant can cause birth defects in the baby. Do not use HCG if you are pregnant. Tell your doctor right away if you become pregnant during treatment. It is not known whether HCG passes into breast milk. Do not use HCG without telling your doctor if you are breast-feeding a baby.

How should I use HCG?

Use HCG exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

HCG is given as an injection under the skin or into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.


Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure HCG is helping your condition, your doctor will need to check you on a regular basis. Do not miss any scheduled appointments.


Some brands of HCG come in powder form with a separate liquid that you must mix together and draw into a syringe. Other brands are provided in single-dose prefilled syringes.

Do not use the medication if it has changed colors or the liquid has any particles in it. Call your doctor for a new prescription. Store unmixed HCG at room temperature away from light, moisture, and heat. After mixing the HCG, you must keep it in the refrigerator until you are ready for your injection. Throw away any mixed medicine that you have not used within 30 days after mixing.

What happens if I miss a dose?

Contact your doctor if you miss a dose of HCG.


What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of HCG is not expected to produce life-threatening symptoms.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using HCG.
HCG side effects

Stop using HCG and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache.


Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:
severe pelvic pain;
swelling of the hands or legs;
stomach pain and swelling;
shortness of breath;
weight gain;
nausea or vomiting; or
urinating less than normal.
HCG can cause early puberty in young boys. Call your doctor if a boy using this medicine shows early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.

Less serious side effects may include:

feeling restless or irritable;
mild swelling or water weight gain;
breast tenderness or swelling; or
pain, swelling, or irritation where the injection is given.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect HCG?

There may be other drugs that can interact with HCG. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.


                           High Purity Children Li Zhu 2000iu / 5000iu HCG Injections For Weight Loss

Quality grade  pharmacy hcg
hcg full name human chorionic gonadotropin
hcg half life 28 hours
hcg dosage

200iu per day

1. Name of the medicinal product

HCG 5000 I.U.powder for solution for injection.


2. Qualitative and quantitative composition

Pregnyl consists of a freeze-dried powder for injection. The active ingredient [human chorionic gonadotrophin (hCG)] which is obtained from the urine of pregnant women, has luteinizing hormone (LH) activity.

An ampoule contains 5000 I.U. hCG.

For a full list of excipients, see section 6.1.


3. Pharmaceutical form

Powder for solution for injection. The powder is a white, dry powder or cake.


4. Clinical particulars
4.1 Therapeutic indications

In the female

Sterility due to the absence of follicle-ripening or ovulation.

In combination with FSH or HMG, promotion of controlled superovulation in medically assisted reproduction programmes.


In the male

Hypogonadotrophic hypogonadism.

Delayed puberty associated with insufficient gonadotrophic pituitary function. Sterility in selected cases of deficient spermatogenesis.


4.2 Posology and method of administration


In the female

Sterility due to the absence of follicle-ripening or ovulation.

5,000–10,000 IU hCG to induce ovulation, following treatment with an FSH (Follicle Stimulating Hormone) or HMG (Human Menopausal Gonadotrophins) preparation.


In combination with FSH or HMG, promotion of controlled superovulation in medically assisted reproduction programmes.

5,000–10,000 IU hCG 30 - 40 hours after the last FSH or HMG injection. Pregnyl should not be administered if the following criteria have not been met: at least 3 follicles greater than 17mm in diameter are present with 17ß estradiol levels of at least 3500 pmol/L (920 picogram/ml). Oocyte collection is carried out 32 - 36 hours after the hCG injection.

As luteal phase support, two to three injections of 1,000 to 3,000 IU hCG each may be given within nine days of ovulation or embryo transfer, for example on day 3, 6 and 9 after ovulation induction or embryo transfer.


In the male

Hypogonadotrophic hypogonadism.

500–1,000 IU hCG 2-3 times weekly.


Delayed puberty associated with insufficient gonadotrophic pituitary function.

1,500 IU hCG twice weekly for at least 6 months.


Sterility in selected cases of deficient spermatogenesis.

Usually, 3,000 IU hCG per week in combination with an FSH or HMG preparation.

This treatment should be continued for at least three months before any improvement in spermatogenesis can be expected. During this treatment testosterone replacement therapy should be suspended. Once achieved, the improvement may sometimes be maintained by hCG alone.


Method of Administration

After addition of the solvent to the freeze-dried substance, the solution should be given immediately by intramuscular or subcutaneous injection. Any unused solution should be discarded. Subcutaneous injection may be carried out by patient or partner, provided that proper instruction is given by the physician. Self administration of Pregnyl should only be performed by patients who are well- motivated, adequately trained and with access to expert advice.


4.3 Contraindications

• Hypersensitivity to human gonadotrophins or any of the excipients listed in section 6.1.

• Presence of uncontrolled non-gonadal endocrinopathies (e.g. thyroid, adrenal or pituitary disorders).

• Breast, uterine, ovarian tumours.

• Vaginal bleeding of unknown cause.

• Known or suspected androgen-dependent tumours such as testicular tumours, carcinoma of the prostate or mammary carcinoma in males.

• Malformations of the sexual organs incompatible with pregnancy.

• Fibroid tumours of the uterus incompatible with pregnancy.


4.4 Special warnings and precautions for use

In the female

• Since infertile women undergoing assisted reproduction, and particularly IVF, often have tubal abnormalities the incidence of ectopic pregnancies might be increased. Early ultrasound confirmation that a pregnancy is intrauterine is therefore important.

• Prior to treating patients for inadequate endogenous stimulation of the gonads, an examination should be performed to exclude anatomical abnormalities of the genital organs or nongonadal endocrinopathies (e.g. thyroid or adrenal disorders, diabetes). Primary ovarian failure should be excluded by the determination of gonadotrophin levels.

• In the pregnancies occurring after induction of ovulation with gonadotrophic preparations, there is an increased risk of abortion and multiplets. Multiple pregnancy, especially high order, carries an increased risk in adverse maternal and perinatal outcomes. The parents should be advised of the potential risks of multiple births before starting treatment.

• The incidence of congenital malformations after Assisted Reproductive Technologies (ART) may be higher than after spontaneous conceptions. This is thought to be due to differences in parental characteristics (e.g. maternal age, sperm characteristics) and an increased incidence of multiple gestations.

• Women with generally recognised risk factors for thrombosis, such as a personal or family history, severe obesity (Body Mass Index > 30 kg/m2) or thrombophilia, may have an increased risk of venous or arterial thromboembolic events, during or following treatment with gonadotrophins. In these women the benefits of IVF treatment need to be weighed against the risks. It should be noted, however, that pregnancy itself also carries an increased risk of thrombosis.

• There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple drug regimens for infertility treatment. It is not yet established whether or not treatment with gonadotrophins increases the baseline risk of these tumours in infertile women.


Unwanted Hyperstimulation

During treatment of female patients, determinations of oestrogen levels and assessment of ovarian size and if possible, ultrasonography should be performed prior to treatment and at regular intervals during treatment. High dosages may cause oestrogen levels to rise excessively rapidly, e.g. more than doubling on 2 or 3 consecutive days, and possibly reaching excessively high pre-ovulatory values.

The diagnosis of unwanted ovarian hyperstimulation may be confirmed by ultrasound examination.

If unwanted hyperstimulation occurs (i.e. not as part of a treatment preparing for IVF/ET or GIFT or other assisted reproduction techniques), the administration of FSH or HMG should be discontinued immediately. HCG must not be given, because the administration of an hLH - active gonadotrophin at this stage may induce, in addition to multiple ovulations, the ovarian hyperstimulation syndrome. This warning is particularly important with respect to patients with polycystic ovarian disease.

Clinical symptoms of mild ovarian hyperstimulation syndrome include gastro-intestinal problems (pain, nausea, diarrhoea, abdominal discomfort and bloating), painful breasts, and mild to moderate enlargement of ovaries and ovarian cysts. Transient liver function test abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, have been reported in association with ovarian hyperstimulation syndrome.

The severe form of ovarian hyperstimulation syndrome may be life-threatening and is characterised by large ovarian cysts (prone to rupture), acute abdominal pain, ascites, weight gain, very often hydrothrax and occasionally thrombo-embolic phenomena.

Pregnyl should not be used for body weight reduction. HCG has no effect on fat metabolism, fat distribution or appetite.


In the male

Treatment with hCG leads to increased androgen production. Therefore:

• Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions) should be kept under close medical supervision, since aggravation or recurrence may occasionally be induced as a result of increased androgen production.

• HCG should be used cautiously in prepubertal boys to avoid premature epiphyseal closure or precocious sexual development. Skeletal maturation should be monitored regularly.


4.5 Interaction with other medicinal products and other forms of interaction

No interaction studies have been performed; interactions with commonly used medicinal products can therefore not be excluded.

Following administration, Pregnyl may interfere for up to ten days with the immunological determination of serum/urinary hCG, leading to a false positive pregnancy test.


4.6 Pregnancy and lactation

Not applicable.


4.7 Effects on ability to drive and use machines

As far as known Pregnyl has no influence on the ability to drive and use machines.


4.8 Undesirable effects

Frequency is unknown for all undesirable effects described below (cannot be determined with available data).

Immune system disorders

In rare cases generalized rash or fever may occur.

General disorders and administrative site conditions

Local site reactions such as bruising, pain, redness, swelling and itching. Oedema. Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site. Tiredness.

Nervous system disorders


Psychiatric disorders

Mood changes.


In the female

Reproductive system and breast disorders

Unwanted ovarian hyperstimulation, mild or severe ovarian hyperstimulation syndrome (OHSS, see section 4.4):


Mild OHSS:

Painful breasts

Mild to moderate enlargement of ovaries

Ovarian cysts

Abdominal pain

Abdominal discomfort

Gastrointestinal symptoms such as nausea, diarrhoea and bloating


Severe OHSS:

Large ovarian cysts (prone to rupture),

Acute abdominal pain


Weight gain


In rare instances, thromboembolism has been associated with FSH/hCG therapy

Not all symptoms described are always associated to OHSS.


In the male

Metabolism and nutrition disorders

Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production.

Reproduction system and breast disorders

HCG treatment may sporadically cause gynaecomastia.

Skin and subcutaneous tissue disorders

Acne may occur occasionally during hCG therapy.


Reporting of suspect adverse reactions

Reporting suspect adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspect adverse reactions via the Yellow Card scheme, at www.mhra.gov.uk/yellowcard.

4.9 Overdose

The toxicity of human chorionic gonadotrophic hormone is very low. However, too high a dose may lead to hyperstimulation of the ovaries. (See “Unwanted Hyperstimulation”).


5. Pharmacological properties
5.1 Pharmacodynamic properties

Pharmacotherapeutic group: gonadotrophins: ATC code G03G A01

Pregnyl is a preparation of human chorionic gonadotrophin obtained from the urine of pregnant women. It stimulates the steroidogenesis in the gonads by virtue of a biological effect similar to that of LH (Luteinizing hormone, which is the same as interstitial cell stimulating hormone). In the male it promotes the production of testosterone and in the female the production of estrogens and particularly of progesterone after ovulation. In certain cases, this preparation is used in combination with human menopausal gonadotrophin (HMG).

Because HCG is of human origin, no antibody formation is to be expected.


5.2 Pharmacokinetic properties

In a study performed in healthy male subjects, maximal hCG plasma levels were reached after a single IM or SC injection of hCG at approximately six and sixteen hours respectively; in addition, maximum concentrations and areas under the concentration curves were higher after the IM than after the SC injection. However, these differences did not translate into significant differences in terms of testicular steroidogenic response.

In a study performed in female subjects under oral contraceptives, IM and SC administration of hCG were found to be bioequivalent regarding the extent of absorption and the apparent elimination half- lives of approximately 33 hours; maximal hCG plasma levels were reached after approximately 20 hours regardless of the route of administration. Although high intersubject variability was observed, the difference related to gender after IM injection may be caused by gluteal fat thickness in women which exceeds that in men. In another study performed in female patients in the early follicular phase of their menstrual cycle, the bioavailability of a single dose of hCG was higher with the IM route than with the SC route and lower in obese women than in non-obese women.

HCG is approximately 80 per cent metabolized, predominantly in the kidneys.

On basis of the recommended dose regimens and elimination half-life, accumulation is not expected to occur.


5.3 Preclinical safety data

There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.


6. Pharmaceutical particulars
6.1 List of excipients

Powder for injection contains:

Carmellose sodium

Mannitol (E421)

Disodium phosphate (anhydrous)

Sodium dihydrogen phosphate (anhydrous)


6.2 Incompatibilities

In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.


6.3 Shelf life

36 months.


6.4 Special precautions for storage

Store in refrigerator (2°C to 8°C). Do not freeze. Keep the ampoules in the outer carton to protect from light.

6.5 Nature and contents of container

2ml ampoule containing freeze-dried powder with 1ml ampoule of solvent (sodium chloride 9mg/ml). Pregnyl is available in packs of 1, 3 or 10 ampoules of powder and solvent.

Not all pack sizes may be marketed.

In correspondence please quote batch number.


6.6 Special precautions for disposal and other handling

Pregnyl should be reconstituted with the solvent provided. Do not use if the solution contains particles or if the solution is not clear. Since an opened ampoule cannot be resealed in such a way to further guarantee the sterility of the contents, the solution should be used immediately after reconstitution. Discard any remaining solution after single use.

Any unused product or waste material should be disposed of in accordance with local requirements.


7. Marketing authorisation holder

Merck Sharp & Dohme Limited

Hertford Road Hoddesdon Hertfordshire



8. Marketing authorisation number(s)

PL 00025/0556


9. Date of first authorisation/renewal of the authorisation

24th February 1991/25th March 2003


10. Date of revision of the text

04 August 2015

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