Marvel Pharma Inc.
Business type: Manufacturer, Distributor/Wholesaler, Exporter, Trading Company, Seller
Telephone : 86-0745-2722878
22nd Floor, New Times Plaza, Hecheng, Huaihua 418000, Hunan CHINA
|Place of Origin:||China|
|Model Number:||Human Menopausal Gonadotropin ( hMG )|
|Minimum Order Quantity:||1 kit|
|Packaging Details:||Discreet packing|
|Delivery Time:||24 hrs|
|Payment Terms:||Western Union, MoneyGram|
|Product Name:||Human Menopausal Gonadotropin HMG 75iu Vial||Specification:||75iu/vial, 6 Vials/kit, 450 Iu/kit|
|Usage:||Used For Treatment In Gonadotropin-deficient Males With Pituitary Dwarfism||HMG Injection Price:||Negotiable|
|HMG Injection Dosage:||Around 75 Iu -150 Iu Per Day||HMG Injection Half Life:||32 Hours|
|HMG Injection Top Color:||Green Tops Hmg||HMG Injection Side Effects:||Severe Pelvic Pain; Swelling Of The Hands Or Legs; Stomach Pain And Swelling; Shortness Of Breath; Weight Gain; Diarrhea; Nausea Or Vomiting; Or. Urinating Less Than Normal.|
Human Menopausal Gonadotropin hMG 75iu vial for treatment in gonadotropin-deficient males with pituitary dwarfism
Human Menopausal Gonadotropin, or hMG, is an injectable fertility drug that contains equal amounts of FSH and LH, sold under the brand names Menopur and Menotrophin.
Human Menopausal Gonadotropin, also known as hMG, is an injectable fertility drug that contains equal amounts of FSH and LH. They are sold under the brand names of Menopur and Repronex. The LH and FSH in these drugs is derived from the urine of post menopausal women who produce the hormones in excessive amounts. The urine is extracted and purified, and then used to make the injectable medications.
hMG’s are used much like other injectable fertility medications. These medications will stimulate your ovaries to induce ovulation while also helping your ovaries to produce one or more eggs. These injections are usually started on day two or three of your period, and continued through days 8 to 14. After that, under a doctor’s watchful eye, a woman will be checked until her follicles are ready and mature. Then, an additional injection of hCG will be given to induce ovulation and then it is time to try to get pregnant!
Human Menopausal Gonadotropins are used to induce ovulation in women with several conditions such as PCOS, Endometriosis, our problems with their pituitary gland (the gland that produces LH and FSH). The injections are given as intramuscular injections, or injections directly into the muscle. The doctor can train a woman or her partner to be able to give the injections at home and not in a doctor’s office setting. The actual act of getting used to giving the injections is usually the hardest part of injectable fertility treatments.
Some women do suffer from side effects of hMG’s. The most common side effect is hyper-ovarian stimulation. This is where too many follicles form inside the ovaries, and it can cause pain and discomfort in the abdominal area. Also common with hMG’s are mood swings, headache, weak or achy feelings, and enlargement or tenderness in the breasts. You should also know that 40 percent of women who get pregnant on hMG’s get pregnant with twins or multiples.
Around 80 percent of women who start taking hMG’s will begin to ovulate within three cycles. Around 60 percent of these women will end up pregnant. That is a great success rate, although of course not all of those pregnancies will be carried to term. You should also be aware that the cost of hMG’s is quite high: around $2000-$5000 for each cycle, and you might need up to six cycles. This medication is not always covered by insurance, so make sure you check with your doctor about that. The cost of the medication does not include other treatments that might be required in conjunction with it, such as IVF or IUI treatments.
What are gonadotrophins?
Gonadotrophins are injectable hormones that can be used to treat fertility problems in women and men. Gonadotrophins help women to ovulate and men to improve their sperm count.
What's the success rate of gonadotrophins?
Up to 85 per cent of women with an ovulation problem will ovulate after using gonadotrophins. About 23 per cent of women with clomifene-resistant PCOS conceive while using gonadotrophins and about 20 per cent have a live birth.
Other factors that can affect conception are:
the time in your cycle you have sex
the speed and ability to move (motility) of your partner's sperm
Gonadotrophins are often used in IVF treatments because controlling the development and release of mature eggs from your ovaries increases your chance of success.
Are gonadotrophins right for me?
You are most likely to be offered these drugs if you:
Have polycystic ovary syndrome and have not ovulated in response to clomifene citrate.
Are having assisted-conception treatments, such as in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
If your partner has a hormonal imbalance linked to a low sperm count, or poor sperm quality or motility, he may be offered gonadotrophins.
Talk to your doctor about your chances of success using these drugs. If you're paying for your treatment, be clear about how much these drugs will cost. This way you can weigh up the pros and cons as best you can before beginning treatment.
How do gonadotrophins work?
The two hormones your body produces that are crucial for ovulation to take place are luteinising hormone (LH) and follicle-stimulating hormone (FSH).
Gonadotrophins are injectable forms of these hormones. They directly stimulate your ovaries to produce and ripen eggs.
The type of gonadotrophins that have been in use for the longest time contain both FSH and LH. These are called human menopausal gonadotrophins (hMG).
Some drugs, called follitropins, now contain only purified FSH. There is not much evidence to suggest that one type of gonadotrophin is better than another at stimulating the ovaries to produce mature eggs, although there may be differences in the cost or availability of some types.
You'll have gonadotrophins in conjunction with another hormone called human chorionic gonadotrophin (hCG). This hormone completes the final stage of egg maturation and can trigger ovulation, too.
How long will I need to be treated with gonadotrophins?
You can begin treatment any time when you're not ovulating. Your course of injections will continue daily for about 12 days each month, depending on how long it takes for your eggs to mature.
Your doctor might teach you how to give yourself the injections so you don't have to travel to the clinic every day. You may want your doctor to show your partner how to do the injections, if you don't want to do it yourself.
While you're having the injections, your doctor will monitor you to see when you're likely to ovulate. This means you'll have frequent ultrasound scans to check your ovaries. The scans will be carried out using a probe inserted into your vagina and shouldn't cause you any discomfort. You may need to have blood tests to check the levels of your hormones, too.
When the scan shows that your eggs are mature, you'll be given an injection of hCG to trigger ovulation. Ovulation usually occurs between 24 hours and 36 hours after the hCG injection.
You and your partner will need to time sex soon after your injection. If you're having IVF, the egg collection procedure will be scheduled for about 36 hours after your injection.
If you're being treated for an ovulation disorder, you're likely to have a maximum of three to six drug cycles. Success rates don't improve if you take the drugs for a longer time. If you try three times or more and don't get pregnant, your doctor may increase the dose or suggest another kind of treatment.
Do gonadotrophins have any side-effects?
It's possible that you may experience any of the following symptoms:
an allergic reaction to the drug
soreness or reaction at the injection site
You may find that giving yourself an injection directly into your muscle, probably your thigh, is difficult as it requires a long needle. The newer, purer gonadotrophins cause fewer side-effects and can be injected using smaller needles under your skin.
Taking these fertility drugs can be an emotionally intense process. As well as all the injections, you'll need to have frequent monitoring.
There's a risk with treatment involving gonadotrophins, and hCG in particular, of developing ovarian hyperstimulation syndrome (OHSS). This is when your ovaries rapidly swell to several times their usual size. Your ovaries may also leak fluid into your abdominal cavity.
Most cases of OHSS are mild. They result in:
mild abdominal pain
Severe OHSS is signalled by:
sudden, severe pain in your belly
thirst and other symptoms of dehydration
If a scan shows that your ovaries are developing too many eggs, you'll be advised not to have sex or exercise strenuously. This is to avoid the risk of injury to your swollen ovaries.
If you're trying to get pregnant without assisted conception, it can be disappointing to have to abandon a cycle of treatment. It's worth being cautious, though, as you also risk having a multiple pregnancy. This can lead to complications for you and your babies.
What else should I know about gonadotrophins?
You'll want to think carefully about the risks before embarking on these treatments. Even with the best monitoring, OHSS can happen.
About a third of IVF cycles are affected by mild OHSS. Between three per cent and eight per cent of cycles are affected by moderate or severe OHSS. The exact rates depend on the types and doses of fertility drugs used.
If you have PCOS, you have a one in three chance of a multiple pregnancy after taking fertility drugs such as gonadotrophins.
Fertility drugs such as hMG don't seem to significantly increase your risk of developing cancer later in life. It's thought that the underlying causes of fertility problems (such as endometriosis), are greater risk factors for some long-term problems, rather than the drugs used to treat them. There is no evidence that using fertility drugs affects the development of children born after their use either.
It is recommended that you always be given the lowest effective dose of fertility drugs for the shortest duration possible. This helps to reduce the risk of side effects, such as OHSS, and complications, such as multiple pregnancy.
What brand names do gonadotrophins go under?
Human menopausal gonadotrophins (hMG) containing LH and FSH go under these brand names:
Follitropins or recombinant FSH (pure FSH) go under these brand names:
Human chorionic gonadotrophin (hCG) goes under these brand names:
You can talk to other women trying to conceive with the help of fertility treatment in BabyCentre's community.
Menotropin (also called human menopausal gonadotropin or hMG) is a hormonally active medication for the treatment of fertility disturbances. Frequently the plural is used as the medication is a mixture of gonadotropins. Menotropins are extracted from the urine of postmenopausal women.
Urine of postmenopausal women reflects the hypergonadotropic state of menopause -levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) are high - and contain a mixture of these gonadotropins. Other protein substances may be present, including small amounts of human chorionic gonadotropin (hCG). In 1949 Piero Donini found a relatively simple method to extract gonadotropins from urine of postmenopausal women. Menotropins were successfully introduced into clinical use by Bruno Lunenfeld in 1961. While earlier menotropin medications contained FSH and LH at a 1:1 ratio, the recognition that it is FSH that is critical for follicle stimulation has led to development of newer preparations that contain a much higher FSH/LH ratio, Fertinex being an example.
Menotropin preparations are designed for use in selected women where they stimulate the ovaries to mature follicles, thus making them more fertile. They are administered by typically daily injection, intramuscularly or subcutaneously, for about ten days under close supervision to adjust dose and duration of therapy. They can also be used in hypogonadal men to stimulate sperm production.
Human urinary-derived menotropin preparations are exposed to the theoretical risk of infection from menopausal donors of urine. Nevertheless, the failure to irrefutably demonstrate infectivity following intracerebral inoculation with urine from transmissible spongiform encephalopathy(TSE)-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.
Recombinant gonadotropins have to a large degree replaced hMG in fertility treatments. The recombinant process allows for the production of pure FSH or LH not "contaminated" by other proteins that may be present after urinary extraction. While some head-on studies seem not to suggest that "pure FSH" gives better results than hMG., others claim that recombinant FSH is more efficient and reduces costs. A Cochrane Collaboration analysis did not reveal major differences in clinical outcomes when comparing urinary versus recombinant FSH.
The Practice Committee of the American Society for Reproductive Medicine reported: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance. There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”
|Quality grade||pharmacy hmg|
|hmg full name||human menopausal gonadotropin|
|hmg half life||32 hours|
75iu -150iu daily
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